Among the highlights are six home underdogs, but the San Francisco 49ers (3-3) are not among them as they prepare to face the undefeated Kansas City Chiefs (5-0), who are the reigning Super Bowl champions. Oddsmakers have placed the 49ers as 1.5-point favorites on BetMGM Sportsbook.
Across the Atlantic, a matchup of struggling teams sees the Jacksonville Jaguars and New England Patriots competing. After a dismal performance during their last outing in London against the Chicago Bears, the Jaguars will move on to play the Patriots at Wembley Stadium.
Meanwhile, the Minnesota Vikings, the NFL’s other undefeated team at 5-0, will host the Detroit Lions (4-1) in a battle for supremacy in a division featuring all winning teams.
Here are the Pro Picks for the upcoming matches, aiming to continue the winning momentum from last week:
**Tennessee Titans at Buffalo Bills**
Line: Bills -9
Quarterback Josh Allen is experiencing an MVP-caliber season, enhanced by the recent acquisition of wide receiver Amari Cooper. The Bills (4-2) will look to maintain their momentum following a Monday night victory over the Jets. Meanwhile, the struggling Titans (1-4) are performing poorly offensively, ranked second to last in yards and averaging only 19.2 points per game.
**BEST BET: BILLS – 30-17**
**Detroit Lions at Minnesota Vikings**
Line: Vikings -2.5
The Lions (4-1), led by quarterback Jared Goff, are having a scoring surge with 89 points over their last two games. However, they face a stiff challenge against the Vikings (5-0), who aim to extend their winning streak after a bye week. Detroit’s defense has performed better recently, but the absence of Aidan Hutchinson could hinder them.
**UPSET SPECIAL: LIONS – 24-23**
**Denver Broncos at New Orleans Saints**
Line: Broncos -2.5
In a significant game for Sean Payton, who returns to New Orleans, the Broncos (3-3) are deemed the better team currently. The Saints (2-4) have struggled lately, losing four straight games. Despite some promise from rookie Spencer Rattler’s performance, their defense is underperforming.
**SAINTS – 19-17**
**New England Patriots vs. Jacksonville Jaguars in London**
Line: Jaguars -5.5
The Jaguars (1-5) have underperformed, confounding expectations after a promising start. Safety Andre Cisco mentioned that players have given up, while the retooling Patriots (1-5) saw rookie quarterback Drake Maye show potential in his debut.
**JAGUARS – 24-20**
**Seattle Seahawks at Atlanta Falcons**
Line: Falcons -3
The Seahawks (3-3) have faced difficulties, losing three in a row after a strong start. Atlanta’s (4-2) offense is versatile, capable of attacking through the air or ground. Seattle’s run defense will need to step up to compete.
**FALCONS – 26-21**
**Cincinnati Bengals at Cleveland Browns**
Line: Bengals -6.5
The Bengals (2-4) are desperate for wins to remain playoff contenders. The Browns (1-5) are struggling with the league’s weakest offense, failing to score 20 points or amass 300 yards in any game so far.
**BENGALS – 23-18**
**Houston Texans at Green Bay Packers**
Line: Packers -2.5
The Texans (5-1) are aiming for a four-game winning streak, bolstered by Joe Mixon’s return to the lineup. The Packers (4-2) are maintaining solid defensive performances but need to be wary of Houston’s momentum.
**PACKERS – 26-23**
**Miami Dolphins at Indianapolis Colts**
Line: Colts -3.5
The Dolphins (2-3) managed a win without Tua Tagovailoa before their bye week. The Colts (3-3) are led by Joe Flacco, who has performed well, and the return of Anthony Richardson could shake up the offense moving forward.
**COLTS – 23-16**
**Philadelphia Eagles at New York Giants**
Line: Eagles -3
Saquon Barkley looks to lead the Eagles (3-2) against his former team. The Eagles’ offense is improving but still finding its rhythm, while the Giants (2-4) are struggling to score points, lacking key offensive players.
**EAGLES – 24-19**
**Las Vegas Raiders at Los Angeles Rams**
Line: Rams -7
It’s unusual for a team with just one win to be favored by a touchdown. The Rams (1-4) are seeking a fresh start after the bye week, while the Raiders (2-4) face uncertainty off the field.
**RAMS – 20-17**
**Carolina Panthers at Washington Commanders**
Line: Commanders -8
The Panthers (1-5) continue to explore their quarterback options with Bryce Young sidelined, while Jayden Daniels has impressed with quick adaptability for the Commanders (4-2).
**COMMANDERS – 27-20**
**Kansas City Chiefs at San Francisco 49ers**
Line: 49ers -1.5
Chiefs coach Andy Reid showcases a formidable record coming off a bye week, and the Chiefs (5-0) aim to maintain their unbeaten status while facing an inconsistent 49ers team.
**49ERS – 26-23**
**New York Jets at Pittsburgh Steelers**
Line: Jets -2
With Davante Adams expected to return, the Jets (2-4) are looking to recover from a few close losses, while the Steelers (4-2) may be evaluating their quarterback options with Russell Wilson considering a debut.
**JETS – 20-16**
**Baltimore Ravens at Tampa Bay Buccaneers**
Line: Ravens -3.5
Lamar Jackson and the Ravens (4-2) have bounced back from a rocky start, while the Buccaneers (4-2) look to exploit their defense’s strengths in this tilting matchup.
**RAVENS – 26-24**
**Los Angeles Chargers at Arizona Cardinals**
Line: Chargers -3
The Chargers (3-2) feature a balanced offense, while the inconsistent Cardinals (2-4) are looking for a turnaround after recent performances.
**CHARGERS – 24-20**
Last week, the record was impressive with 12 wins out of 14 games straight up and 11 against the spread.
Overall performance to date stands at 62 wins and 30 losses straight up, and 52 wins against the spread with two ties.
This includes a solid showing on Thursdays and a split record on Mondays.