Los Angeles Rams (7-6) are set to clash with the San Francisco 49ers (6-7) on Thursday at 8:15 p.m. EST, available for viewing on Amazon Prime Video.
According to BetMGM NFL odds, the 49ers are favored by 2.5 points.
In terms of spread records, the Rams are currently at 6-7, while the 49ers sit at 5-8.
Historically, the 49ers hold the advantage with a series record of 78-70-3.
In their last encounter, the Rams secured a narrow victory, defeating the 49ers 27-24 in Inglewood, California, on September 22, 2024.
Last week, the Rams celebrated a close win against the Bills, finishing 44-42, while the 49ers enjoyed a more dominant performance, beating the Bears 38-13.

Analyzing the offense, the Rams rank 15th overall, 25th in rushing, 9th in passing, and 16th in scoring.
Their defense, however, is struggling significantly, placing 27th overall, 28th against the run, 24th in pass defense, and 24th in scoring defense.
Conversely, the 49ers’ offense is considerably stronger overall, ranking 4th, with 7th in rushing, 7th in passing, and 11th in scoring.
Their defense is also formidable, sitting 3rd overall, 12th against the rush, 3rd in pass defense, and 21st in scoring.
The Rams have a turnover differential of plus-3, while the 49ers stand at minus-3.

Focusing on individual performances, Rams quarterback Matthew Stafford dazzled against the Bills, accumulating 320 yards and two touchdowns.
This marked the fourth game this season without a sack for Stafford, contributing to a flawless record in these outings and illustrating his effectiveness with 12 touchdowns to only two interceptions.
In their previous matchup in Week 3, the 49ers managed to sack Stafford three times, the most he has faced in a Rams victory this season.
However, by this week, the Rams’ offensive line has shown improvements from earlier in the season.

On the 49ers’ side, wide receiver Jauan Jennings had a standout performance last week with seven receptions for 90 yards and two touchdowns, bringing his season total to six.
Remarkably, Jennings had previously recorded just seven touchdown catches over his first three seasons.
He notably excelled against the Rams in their Week 4 matchup earlier in the season, accumulating 11 catches for 175 yards and three touchdowns.

A crucial matchup to watch will be between Rams wide receiver Cooper Kupp and 49ers defensive back Deommodore Lenoir.
Kupp, despite missing four games this season, ranks fourth in the league with 44 slot catches.
Lenoir has stepped up as a key slot defender, posing a significant challenge as he matches up with Kupp.

In terms of injuries, the Rams will be without cornerback Cobie Durant, who suffered a lung contusion in the game against the Bills.
Rookie center Beaux Limmer is questionable due to a knee injury.
For the 49ers, they will miss left tackle Trent Williams, safety Malik Mustapha, and guard Ben Bartch, all due to ankle injuries.
Defensive end Nick Bosa is also questionable following a three-game absence due to an oblique injury, while running back Isaac Guerendo remains a game-time decision with a foot issue.
A notable return could be linebacker Dre Greenlaw, who may make his season debut after recovering from an Achilles tendon tear sustained during last season’s Super Bowl.

From a historical perspective, the Rams have won their last two encounters and are aiming for a three-game win streak against the 49ers, which they haven’t achieved since the late ’90s-early 2000s.
Additionally, the Rams have not swept the season series against San Francisco since 2018.
Coaching matchups see San Francisco’s Kyle Shanahan holding a 10-6 record against the Rams’ Sean McVay.

Statistically, Stafford has endured only six sacks during the Rams’ seven victories but has faced 22 sacks in six losses.
Impressively, Los Angeles converted 73.3% of their third downs in last week’s game against Buffalo, reflecting their most efficient performance since a game against Indianapolis in 2001.
Rookie wide receiver Puka Nacua has made an extraordinary impact with 2,194 receiving yards and 159 receptions across his first 25 games, ranking second in NFL history.
The Rams defense has struggled recently, failing to force a turnover in the last three outings and not recording a sack in the last two games.
Running back Kyren Williams performed well in the previous match against the 49ers, rushing for 89 yards and two touchdowns.
Kupp hasn’t faced the 49ers since October 2022 but has a strong record of 66 receptions for 700 yards and five touchdowns across 10 games against them.

This season, the 49ers possess a lackluster division record of 1-3, having squandered leads in all three losses, a stark contrast to their previous two seasons where they dominated their NFC West rivals.
The Niners recorded nine plays exceeding 20 yards last week against Chicago while preventing any big plays from their opponents.
Moreover, they’ve shown defensive strength by allowing only five rushes of over 20 yards this season.
Last week’s performance included their first seven-sack game since 2022, led by Yetur Gross-Matos, who achieved a career-best with three sacks.
However, they’ve faced challenges in the red zone, allowing touchdowns on 11 consecutive attempts.
Defensive end Leonard Floyd has accumulated 5.5 sacks over the past four games, and tight end George Kittle had an impressive game with six catches for 151 yards.
Kittle’s total now stands at 516 receptions for 7,074 yards, marking him among an elite group of tight ends in NFL history.
Quarterback Brock Purdy also had a standout performance, completing 20 of 25 passes for a season-high 325 yards.

In a fantasy tip, 49ers wide receiver Deebo Samuel has struggled lately with only 97 yards from scrimmage over the past four games.
He has voiced a desire for more involvement, and given his historical success against the Rams, he may find himself more targeted in upcoming plays.