The pair of Hall of Fame-caliber running backs, Saquon Barkley and Derrick Henry, will clash as the Philadelphia Eagles (9-2) take on the Baltimore Ravens (8-4) in what could be a preview of the Super Bowl. Barkley currently leads the league with 1,392 rushing yards, closely followed by Henry who has amassed 1,325 yards.
In another intriguing game, the Los Angeles Chargers (7-4) will travel to meet the Atlanta Falcons (6-5). Here, two rookie head coaches have managed to steer their teams in a positive direction this season. Additionally, fans will get to see a surprising showdown as the Minnesota Vikings (9-2) host the Arizona Cardinals (6-5).
The full schedule for the week kicks off with three games on Thanksgiving Day and continues with additional matchups on Black Friday.
This week’s betting odds indicate that five visiting teams are favored, according to BetMGM Sportsbook. Pro Picks is gearing up for another successful week.
**New York Giants (2-9) at Dallas Cowboys (4-7)**
Line: Cowboys -3.5
The Giants are currently facing serious challenges, with general manager Joe Schoen and head coach Brian Daboll’s jobs seemingly on shaky ground. Other issues include the potential for Drew Lock to step in as a third starting quarterback within three games. Rookie star Malik Nabers didn’t hold back, calling his team “soft” after their lackluster performance last week. Comparatively, the Cowboys, who recently secured an upset victory against Washington, are trying to capitalize on a softening schedule to stay in playoff contention. Despite losing their last six home games, they have a strong historical edge over the Giants.
**BEST BET: Cowboys 26-17**
**Los Angeles Rams (5-6) at New Orleans Saints (4-7)**
Line: Rams -2.5
Under interim coach Darren Rizzi, the Saints have managed to secure two victories and are eager to maintain their postseason aspirations following a bye week. After a rocky season start, their offense appears to be regaining momentum, highlighting a rejuvenated run game along with solid performances from quarterback Derek Carr. Running back Alvin Kamara will look to capitalize against a Rams defense that struggled against the run last game. For the Rams, improving protection for quarterback Matthew Stafford is crucial.
**UPSET SPECIAL: Saints 24-23**
**Chicago Bears (4-7) at Detroit Lions (10-1)**
Line: Lions -9.5
The Lions are looking to snap a streak of seven consecutive losses on Thanksgiving, with three of those losses coming from the Bears. After a tough start earlier in the season, the Lions have bounced back strong, recording nine consecutive victories. The defense has been resilient, maintaining a two-game touchdown-free streak while Jared Goff leads the offensive charge. The Bears are in a desperate position, hoping to end a five-game losing spree, but will face a formidable competitor.
**LIONS 31-19**
**Miami Dolphins (5-6) at Green Bay Packers (8-3)**
Line: Packers -3.5
The last encounter between the Dolphins and Packers saw Tua Tagovailoa sustain a season-ending concussion; however, he has since returned in impressive form, leading his team to consecutive wins. Meanwhile, the Packers must navigate through a tight schedule, facing Miami just before a key division clash against the Lions next week. Jordan Love has shown promise after two challenging games but will face a big test against a strong Dolphins defense.
**PACKERS 23-21**
**Las Vegas Raiders (2-9) at Kansas City Chiefs (10-1)**
Line: Chiefs -13
Surprising but effective, the Chiefs have continued their winning streak despite close outcomes, notching up their twelfth consecutive win decided by fewer than seven points. Even with Patrick Mahomes leading the charge, Kansas City is looking for a dominant performance against the struggling Raiders, who are desperate for a win. Facing an uphill battle, Las Vegas will be starting Aidan O’Connell in the aftermath of Gardner Minshew’s struggles.
**CHIEFS 27-16**
**Los Angeles Chargers (7-4) at Atlanta Falcons (6-5)**
Line: Chargers -2
After losing in the “Harbowl,” the Chargers have to regroup quickly for their away game. Their inconsistent offense might miss running back J.K. Dobbins, while the defense has allowed 57 points over the past two weeks. On the flip side, the Falcons are looking to pause their recent struggles and maintain their foothold in the NFC South as they come off a bye week.
**FALCONS 23-22**
**Pittsburgh Steelers (8-3) at Cincinnati Bengals (4-7)**
Line: Bengals -3
Pittsburgh’s leadership in the AFC North is now at stake as they stumble after a loss to Cleveland. With the spotlight on quarterback Russell Wilson, the Steelers must manage the growing expectations as they face off against Joe Burrow and company, trying to capitalize on their playoff hopes.
**BENGALS 24-23**
**Arizona Cardinals (6-5) at Minnesota Vikings (9-2)**
Line: Vikings -3.5
The Vikings have risen as a surprise contender this season thanks to a strong defense. Despite a recent setback, they hold a favorable position compared to the struggling Cardinals. With Kyler Murray’s offense facing challenges, it won’t be an easy task to succeed against Minnesota.
**VIKINGS 23-17**
**Indianapolis Colts (5-7) at New England Patriots (3-9)**
Line: Colts -2.5
This is a far cry from the legendary battles between Tom Brady and Peyton Manning as young quarterbacks Anthony Richardson and Drake Maye take center stage now. The Colts have struggled to find consistency, but they might find hope against the struggling Patriots.
**COLTS 20-16**
**Seattle Seahawks (6-5) at New York Jets (3-8)**
Line: Seahawks -2
In a matchup filled with narratives, Geno Smith faces off against his former team as Seattle seeks playoff contention amid an unraveling Jets squad. With coaching changes and uncertainty surrounding the franchise, the Jets remain a team with talent despite their struggles this season.
**SEAHAWKS 20-17**
**Tennessee Titans (3-8) at Washington Commanders (7-5)**
Line: Commanders -6
After three straight losses, the Commanders are eyeing a recovery against a Titans team that has shown resilience. The Titans possess one of the top-ranked defenses in the league, which will pose a significant challenge for Washington to overcome.
**COMMANDERS 24-17**
**Houston Texans (7-5) at Jacksonville Jaguars (2-9)**
Line: Texans -4.5
Though the Texans have faced their share of struggles, they have been significantly better than the Jaguars this season. The potential return of Trevor Lawrence could improve Jacksonville’s chances, but the history doesn’t favor them against Houston, who have traditionally dominated this matchup.
**TEXANS 24-20**
**Tampa Bay Buccaneers (5-6) at Carolina Panthers (3-8)**
Line: Buccaneers -6
Under Dave Canales, the Panthers are showing signs of improvement. Despite their struggles, the Buccaneers need to maintain their momentum and focus on their playoff aspirations as they gear up for this critical game against Carolina.
**BUCCANEERS 24-20**
**Philadelphia Eagles (9-2) at Baltimore Ravens (8-4)**
Line: Ravens -3
Both teams are entering this matchup after impressive wins, raising the stakes as they look to enhance their playoff standings. With star players on both sides making impactful contributions, expectations are high. However, the Eagles might hold the edge with their robust defense.
**EAGLES 26-23**
**San Francisco 49ers (5-6) at Buffalo Bills (9-2)**
Line: Bills -7
The 49ers are reeling from injuries and struggling for consistency as they meet a Bills team that is coming off consecutive victories. With key players returning, Buffalo looks primed to assert its dominance in this critical game.
**BILLS 26-23**
**Cleveland Browns (3-8) at Denver Broncos (7-5)**
Line: Broncos -5.5
Jameis Winston’s revitalization of the Browns’ offensive strategy has come too late to affect their postseason but has sparked some interest. The ever-improving Broncos, led by rookie quarterback Bo Nix, are in the hunt for a playoff spot—benefiting significantly from a strong defense.
**BRONCOS 23-19**
**Last week: Straight up: 9-4. Against spread: 8-5.
Overall: Straight up: 121-68. Against spread: 97-80-2.
Prime-time: Straight up: 28-12. Against spread: 21-18-1.
Best Bet: Straight up: 8-4. Against spread: 7-5.
Upset Special: Straight up: 7-5. Against spread: 7-5.**