U.S. stock markets experienced their largest decline since Election Day, as the growth following Donald Trump’s recent victory and the Federal Reserve’s decision to lower interest rates began to diminish.

On Friday, the S&P 500 index decreased by 1.3%, marking the conclusion of a challenging week. The Dow Jones Industrial Average fell by 0.7%, while the Nasdaq composite saw a drop of 2.2%.

The market was negatively impacted by news surrounding vaccine manufacturers, including Moderna, particularly after President-elect Trump appointed Robert F. Kennedy Jr., a known anti-vaccine advocate, as his choice for health secretary. Additionally, Treasury yields fluctuated in response to economic reports that came in stronger than anticipated.

On Friday’s market close:

The S&P 500 fell by 78.55 points, or 1.3%, settling at 5,870.62.

The Dow Jones Industrial Average dropped 305.87 points, or 0.7%, to end at 43,444.99.

The Nasdaq composite experienced a decline of 427.53 points, or 2.2%, closing at 18,680.12.

The Russell 2000 index, which reflects smaller company stocks, decreased by 33.10 points, or 1.4%, to close at 2,303.84.

Looking at the broader picture for the week:

The S&P 500 recorded a decline of 124.92 points, equating to 2.1%.

The Dow experienced a drop of 544 points, or 1.2%.

The Nasdaq was down 606.66 points, which represents a decrease of 3.1%.

The Russell 2000 index saw a significant drop of 95.80 points, or 4%.

When evaluated year-to-date, the performance remains positive:

The S&P 500 has risen by 1,100.79 points, a growth of 23.1%.

The Dow has increased by 5,755.45 points, or 15.3%.

The Nasdaq boasts an increase of 3,668.77 points, reflecting a rise of 24.4%.

The Russell 2000 has gained 276.76 points, translating to an increase of 13.7%.