New England (1-2) is set to face off against San Francisco (1-2) on Sunday at 4:05 p.m. EDT on FOX. The BetMGM NFL odds favor the 49ers by 10 points. The 49ers hold a historical series lead of 9-5 against the Patriots. In their last meeting on October 25, 2020, the 49ers secured a victory with a score of 33-6 in Foxborough, Mass. Last week, the Patriots suffered a 24-3 loss to the New York Jets, while the 49ers lost 27-24 to the Los Angeles Rams.

In terms of offensive statistics, the Patriots rank low in overall offense (32nd), passing offense (30th), and scoring offense (31st) but have a strong rush offense (8th). On defense, the Patriots are performing better, with a ranking of 19th overall and 5th against the run. Meanwhile, the 49ers boast a powerful offense, ranking 3rd overall, 2nd in passing, and 9th in scoring. Defensively, the 49ers rank 16th overall and 9th against the run.

The turnover battle between the two teams is fairly even, with both the Patriots and 49ers having a turnover differential of plus-1. One player to keep an eye on for the Patriots is running back Rhamondre Stevenson, who has been impactful despite a recent decline in rushing yards. For the 49ers, wide receiver Jauan Jennings stood out in the last game with an impressive performance.

An important matchup to watch is between Patriots defensive end Keion White and 49ers right tackle Colton McKivitz. White, a standout edge rusher this season, will look to exploit McKivitz’s vulnerabilities on the offensive line. Both teams have seen key players return from injuries ahead of this crucial matchup.

In terms of series history, the Patriots have won their past two road games against the 49ers. However, 49ers’ head coach Kyle Shanahan emerged victorious in their most recent encounter in 2020. The Patriots have yet to throw an interception this season, showcasing strong ball security.

Fantasy football players may want to keep an eye on San Francisco WR Brandon Aiyuk, who has had a slow start to the season but could bounce back as he shakes off his rust from missing practice during training camp due to a contract dispute.Overall, the upcoming matchup between the Patriots and the 49ers promises to be an exciting game with both teams aiming to improve their standing in the league.