The upcoming NFL matchup between the Jacksonville Jaguars and the Buffalo Bills is set to take place on Monday at 7:30 p.m. EDT, airing on ESPN. The Bills are favored to win by 5 1/2 points according to BetMGM NFL Odds. The Jaguars currently lead the series between the two teams, with a record of 10-9.

In terms of recent performances, the Jaguars are coming off a loss to the Browns, while the Bills secured a victory against the Dolphins last week. Both teams have a 1-1 record against the spread. The last meeting between the two teams ended in a 25-20 victory for the Jaguars in London on Oct. 8, 2023.

Key players to watch in the upcoming game include third-year linebacker Baylon Spector for the Bills, who will be stepping in for the injured Terrel Bernard, and Josh Hines-Allen for the Jaguars, who has a history of standout performances against his former namesake, Josh Allen.

In terms of injuries, the Bills will be without Bernard and cornerback Taron Johnson, while the Jaguars are not expecting tight end Evan Engram and cornerback Tyson Campbell to play.

Both teams have had success in the series over the years, with the Jaguars winning four of the past six meetings. The Bills, however, have won the last three meetings at Orchard Park, New York.

Fantasy players may want to consider starting Bills QB Josh Allen and RB James Cook, as they have been consistent point-producers. The rest of the Bills’ receiving corps may be best kept on the bench until a clear hierarchy emerges in the offense.

Overall, the upcoming game promises to be an intriguing matchup between the Jaguars and the Bills, with both teams looking to secure a pivotal victory early in the season.