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Seattle (4-5) will face San Francisco (5-4) in an exciting matchup on Sunday at 4:05 p.m. EST, broadcast on Fox.
The odds from BetMGM indicate San Francisco is favored by 6.5 points.
In terms of performance against the spread, Seattle stands at 2-6-1 while San Francisco is at 4-5.
Historically, the Seahawks have the edge in their rivalry with a series record of 30-23, although the 49ers won the most recent encounter 36-24 in Seattle on October 10.
Last week, the Seahawks were on a bye after a tough overtime loss to the Rams, while the 49ers secured a narrow victory against the Buccaneers, winning 23-20.

Diving into statistics, the Seahawks’ offense ranks overall at 9th place, with their passing attack leading the league at 1st, although they sit at 27th in rushing and 15th in scoring.
However, their defense has struggled, currently ranking 25th overall, with 26th in rush defense, 20th in pass defense, and 23rd in scoring defense.
In contrast, the 49ers’ offense boasts impressive numbers, coming in 2nd overall, with their rushing game at 5th, passing game at 2nd, and scoring at 7th.
San Francisco’s defensive unit is also solid, ranking 9th overall, with their rush defense 8th, pass defense 12th, and scoring defense 17th.
When looking at the turnover differential, the Seahawks sit at minus-6, whereas the 49ers are at plus-3.

For the Seahawks, a key player to keep an eye on is wide receiver DK Metcalf, who is likely to return after missing the previous two games due to an MCL sprain suffered on October 20 against Atlanta.
Despite being sidelined, Metcalf leads the Seahawks in receiving this season with 568 yards on 35 receptions.
On the 49ers’ side, quarterback Brock Purdy had a standout performance last week, throwing for 353 yards and two touchdowns against the Buccaneers.
He holds an impressive 118.0 rating in games against Seattle, and he remains undefeated in five career starts versus them, including a playoff confrontation.

A crucial area to watch in this matchup will be special teams, where Seattle’s Laviska Shenault Jr. had a mixed outing in their first meeting — he fumbled on one return but also returned another kick 97 yards for a touchdown.
The 49ers have faced issues on special teams this season, highlighted by a fumbled punt and missed field goals in their recent game.

In terms of injuries, the Seahawks activated right tackle Abe Lucas from the PUP list, which means he could see his first action since suffering a knee injury last season.
However, tight end Noah Fant, tight end Brady Russell, and defensive end Leonard Williams missed early week practices.
On the 49ers’ side, tight end George Kittle and defensive end Nick Bosa are dealing with injuries but are expected to play.
Defensive end Yetur Gross-Matos may return from injured reserve this week.
Additionally, punter Mitch Wishnowsky’s participation is uncertain due to a back issue, with Pat O’Donnell brought in as his potential replacement.

Series history shows the 49ers currently on a six-game winning streak against the Seahawks, marking their longest stretch of success in this rivalry.
It’s been quite some time since these teams split their season series, and Seattle managed to sweep in 2020-21 while San Francisco took both encounters last season.
Notably, the Seahawks are among the top teams in road victories since 2013, holding an impressive 2-1 record away from home this season.
Seattle is looking to reach a franchise milestone of 400 wins, while wide receiver Tyler Lockett needs just 19 yards to surpass 13,000 combined yards, aiming for a spot in the franchise’s record books.
Quarterback Geno Smith is one 300-yard game away from tying Russell Wilson for the most in a single season.
Meanwhile, Metcalf is on the verge of breaking records for the most receiving yards and touchdowns in the franchise’s history for players in their first six seasons.
The 49ers, meanwhile, are riding a two-game winning streak for the first time this season, looking to improve their division performance, and they currently excel in offensive plays.

In fantasy football, keep an eye on San Francisco wide receiver Jauan Jennings, who has stepped up well in the absence of starter Brandon Aiyuk, recording seven catches for 93 yards last week, marking a career best in total yards this season.

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