The upcoming NFL matchup between the Washington Commanders and Arizona Cardinals is set to take place on Sunday at 4:05 p.m. EDT, airing on Fox. According to BetMGM NFL odds, the Cardinals are favored to win by 3 1/2 points, with both teams holding a 2-1 record against the spread. The Commanders lead the overall series record with 77 wins compared to the Cardinals’ 47 victories, with 2 ties.

In their last meeting on September 10, 2023, the Commanders emerged victorious with a 20-16 win over the Cardinals in Landover, Maryland. The Commanders are entering the game with momentum after defeating the Cincinnati Bengals 38-33 last week, while the Cardinals suffered a 20-13 loss to the Detroit Lions.

Key players to watch in the upcoming game include Commanders’ running back Brian Robinson Jr., who will play a crucial role in the absence of Austin Ekeler. On the Cardinals side, wide receiver Michael Wilson is expected to make significant contributions, especially with defenses focusing on rookie standout Marvin Harrison Jr.

A key matchup to watch is how the Cardinals’ pass rush, which has recorded nine sacks in three games this season, will challenge Commanders quarterback Jayden Daniels. The Commanders will need to maintain a balanced offensive attack to counter the Cardinals’ defensive pressure.

In terms of injuries, both teams have players listed on injured reserve and in concussion protocol. Maintaining player health and depth will be essential for both teams as they compete in this critical matchup.

Statistically, the Commanders have had recent success against the Cardinals, winning 11 of their last 15 matchups since 2000. The two teams have a long history, having faced each other 127 times dating back to 1932.

Fans and fantasy football enthusiasts should keep an eye on Cardinals running back James Conner, who is poised for a bounce-back performance after a slow game last week. Conner has a track record of following up low-yardage games with standout performances.

Overall, the upcoming game between the Commanders and Cardinals promises to be a thrilling matchup with players to watch, key injuries to monitor, and statistical trends favoring the Commanders in recent years.