The San Francisco 49ers and the Minnesota Vikings, both standing with a 1-0 record, are set to face off on Sunday at 1 p.m. EDT, with CBS broadcasting the game. The odds favor the 49ers by 5½ points according to BetMGM. These teams have a close series record, with the 49ers leading 25-24-1.

In their last matchups, the 49ers defeated the Jets 32-19, while the Vikings secured a victory against the Giants with a score of 28-6. The 49ers’ offense ranks 5th overall, excelling in rushing (3rd) and passing (10th) categories, with a scoring rank of 6th. On the defensive side, the 49ers rank 10th overall, with a strong rush defense (2nd).

The Vikings’ offense ranks 14th overall, performing moderately in rushing (18th) and passing (12th), while ranking 9th in scoring. Defensively, the Vikings rank 7th overall, boasting a solid rush defense (6th).

Players to watch in this matchup include WR Jalen Nailor from the Vikings, who showed promise with a touchdown reception in the previous game, and RB Jordan Mason from the 49ers, who had an impressive performance filling in for the injured Christian McCaffrey.

A key matchup to look out for is Vikings RT Brian O’Neill facing off against 49ers DE Nick Bosa, who has been a formidable pass rusher. Both teams have notable injuries to key players, impacting their strategies for the upcoming game.

The 49ers aim to secure their fifth 2-0 start since 2010, a good omen considering their past successes following such starts. On the other hand, the Vikings seek to maintain their strong performance from Week 1. Fans can expect an exciting game with both teams showcasing their strengths and adapting to key injuries on the roster.